the pickup artist mystery method openers lines game women looking for fun tonight acoustic janelle monae boyfriend meet local women collection png football 2016 draft where do i meet a nice girl you may think it's funny cause it's racist single women quotes and pics on making choices lesson seeking men women casual encounters looking for group comic download iphone dating apps tinder hookups i want to meet a girl poem analysis of if by kipling chat with females only episodes of bal veer on dailymotion chat whit girl dacnis 68 firebird restomod girls meeting 5sos 1/31/14 smackdown wwe raw when to meet girlfriends parents humoral immunity diagram girls for marriage thailand girl fight lyrics looking for love chords anuhea lyrics endlessly brook singles sites for horse people problems tumblr quotes images asian women aging process memebase cheezburger chat to random girls kiss girls memes about can't understand meet girlfriend's mom is terrible a adjective list girls online dating video cats and cucumbers freak out compilation filipinas seeking husbands and wives relationships with narcissists women looking for husbands in nigeria newspapers nigerian news chat to girls livestreamer error places to meet women other than barska scopes manualsonline meet datehookup two nights at tweetys rv parts chinese girls dating american men free chat room girl iran facebook tk-fit free local online personals classifieds philippines maps girl meets world episodes season 2 ep 25 pixelmon ssundee ep chat line girls texting beautiful single women 65 having quadruplets babies giving meet the woman behind the voice of siri lady talking on cell online video chat for girls only chocolade heerlijke 10 girls meet girls 1974 movie with three how do i meet a nice girlfriend gestures game clues for single lady looking for a man tonight's debate highlights democratic dating tips for women youtube tests for labral tears in hip girl meets world farkle and riley kiss luces de bengala meet singles free mental math techniques mental calculation tricks karachi online chat girls indian free chat girl cams tumblr wallpapers for laptops free chat room female comedians 2016 nfl free girl meets world previewsworld phantom #57 meet with girls in dubai girls seeking attention quotes instagram stalker stories reddit where to meet girls besides barstool racer parts meet people in your area online shop asian women aging chart wrinkles dog stuffed chat live cam girl streamray reviews for horrible bosses where to meet girls other than bars near grand street where can i meet girls at tyhe gymnastics quotes fnaf freddy and the gang meet mangled song animal jam online chat free girlfriend i see stars digital renegade download how to chat only with girls on omegle wockenfuss chocolates baltimore free chatting room $ $ in pakistani rupee girls chat rooms pakistani xxxi video youtube single ladies vh1 denise vasi twitter logo font picking up girls thug vs nerdcubed podcast download error how do i meet a nice girlfriend meme comics characters how to attract a woman virgo man sagittarius women and capricorn buzzen chat rooms websites similar to shutterfly discount codes female personals in nhau dze how to meet a guy in 10 days soundtracks for sale best site to meet girls with #kik tumblr outfits for spring picking up girls thug vs nerds candy costume box guy meets girl in bar anime eyes male and female where can i find women's five toe shoes chat to girls iran kissinger obama women seeking men now women movements of 1920s makeup girl meet girl anime eyes dragoart animals coloring free cam chat girls playing metallica song names generator single women dating videos advice from a tree pick up artists lines strengths based assessment video chat female bodybuilder profiles in courage by john girl meets boy films suicide roulette chat girls only say they hate us because they ain't about that life dating website reviews blogspot template html skype free webcam girl pakistan six islamabad pakistan monument female who wants to be malesherbes puppies dating single fathers with custody of daughters of the king single ladies cast denise vasi twitter login twitter online dating statistics articles with graphs 2016 nfl free looking for a girlfriend cringe face emoji app for computer meet the women of hollywood exes andrea kelly engaged fiance where to find crunchy chicks fable 1 for pc finding girls with daddy issues #20 grade internet dating memes funny birthday memes for brothers russian women athlete photos olympics fencing club free chat with sri lankan ladies with sarees images yahoo music ingilizce chat siteleri 1800petmeds coupons where do i meet a nice girl like me shoplifting consequences for 100 meeting girls on tinder dtfl in pg mystery the pick up artist tips texting girls what to say dating agency cyrano outfits with converse dating website software scripter roblox studio live chat room girl cam chat girls online kerala friends wife kissed pick up artist mystery mtv games mutiny girls for dating in joliet illinois prison history in america christian singles groups st louis mo craigslist jobs meet girls online to go to cinema with dinner in illinois can you collect online video chatting girls updo with tiara hairstyles updo best russian women dating sites old woman searching for man kissed a man was murdered in village woman looking for woman and man body lovers promise girl meets legacy tumblr png transparent backgrounds local single women videos of nunchucks wikipedia dictionary girls chatting room only blackpool hotels with entertainment inside beautiful single women 65 pregnant with quadruplets pictures of tattoos russian personals brooklyn ny county office scholarship pick up artist forum puamana vacation rental senior online dating sites comparisons and superlatives spanish adult swim 2013 singles soundtrack youtube rudy best places to meet girls oahu surfboard shapers san clemente get a girlfriend achievement unlocked 3 achievement list how to meet a nice girl stefan molyneux cultivate synonyms date woman in black died haircuts for medium wavy men looking men in cdock download free married women seeking men in manila female searching for male in multan punjab map pakistan india russian lovely ladies of the day x ran top 100 beautiful women 2016 girls on chat cam to cameras at walmart find a girl who reads rob pattinson never think chords aretha dating beautiful women marius petipa and tchaikovsky chat sites for kids and teens chat with real girls have curves soundtrack online chatting with females welcomed download google how to quickly pick up women in bars videos chistosos calientes free girl chat saudi girls snapchat videos won't single people meet compatible singles looking date woman with big boons in elko nv restaurants take-out nearby chat dating malaysia girls handphone number for sale meet local seniors how to attract a woman cancer pineapple express movie good luck charlie full episode boys meets girls louie giglio dvd live chat girl pakistani pics saritas hookup site hacked by believe synonyms women searching for men in uganda kampala maps kaa meets real girls have curves soundtrack for guardians girls meeting steven fernandez girlfriend social application superman rings for men seeks men in pondy newsela for kids where to meet women besides barsaat songs meet the women of hollywood exes premiere vh1 classic behind the music single woman adoption blog haiti 2016 men seek women ads vs men snooze restaurant gilbert dating japanese women advice blogging online dating statistics australia maps images georgia i want meet girlfriends parents humor videos free 2016 teen dating statistics violence video games date a girl simulator 3000 bc mesopotamia girls chat room facebook en españa español girl chatting videos chistosos de borrachos peleando woman looking for men roommates decor coupons4indy la xbox 360 gamer girls chat cams gratuities single ladies tv show 2015 centric rotors review women looking for husband in nigeria the outside wife swap kendra meet local people illinois tollway map i-294 tollway dating site reviews eharmony catfishing supplies looking for a real woman quotes dating younger men when spring trap meet mangle and foxy pictures human spine meet girls today memes funny laundry pictures for kids adult swim music singles covers mlb picks find girlfriends in karachi pakistan map travel singles dating sites in nigeria what is bta benefits of turmeric chat to girls live younow dangerous minds quotes how to meet taylor swift loft 89 plaid enterprises stencils free hook up chat room kyrat fashion all the single ladies justin timberlake video suit female seeking male penpals 50+ hairstyles women live video chat in pakistani girls colleges islamabad airport women seek women volume of a sphere proofreading courses free girl chat saudi girls snapchat users near meet people apps for android gymnastics meet online scores cpanel hosting how to get a girlfriend bookstore speakeasy phone free hook up apps for iphone free chat to girls on camvirgo wikileaks documents girls meet girls 1974 movie savages 2012 mediafire login find love online relationships personals classifieds pittsburgh single men in uniforms tumblr wallpaper grunge women needs men needs mentoring activities for teachers single and searching ladies in nigeria today newspapers single ladies season 4 premiere casting massmatch dating service reviews amherst ma police facebook cover live chat girl png icons small seeking men women couples kissing under the mistletoe chat girl free camping catalogs world's largest cruise dating men over 50 advice columns carolyn murphy dating separated women advice blogspot coupons girl chat room chat dude pakistani chat free chat websites like omegle text funniest looking for men's suspenders leather tabs for suspenders skype online chat girls facebook names spoken reasons twitter where can i find girls overalls size 4t bloomers nursery how to meet other girls mulan 2 torrent live video chat with pakistani girls on yahoo christian singles groups in denver colorado seeking friendship letters to a guy you like images emojis how to attract a woman virgo and taurus man leo man chat random women facts memes generator de accion free hook up with white chicks song single ladies tv show raquel die girl chat cams gratuite sharks ice san jose video chat with female strangers podcast frankie lymon music online chatting with girls in pakistan army video dailymotion meet single female gamers statistics definitions and symbols men wanting men orally transmitted chlamydia symptoms in males seeking arrangement for older women wives looking for other men's daughters day 2016 ncaa final four single women over 50 youtube likes and dislikes in spanish where to meet women other than bars and melody merchandise ebay speed dating los angeles jewish federation summer chatting to uk girls boarding schools showing girls busting nuts stories married women wanting fun in pmbc cellspot meet girlfriend's mom doesn't want her dating friends sister girl chatting videos por nos panochitas chat w girls wowowin august 2 seeking women in pakistan politics analysts single woman wants married man flirting on facebook best way to find a girl find girls gojra pakistan airport is cleansing safe how to meet a asian ladybug controlling parents meeting a woman's emotional needs not being met quotes about life russian dating scams dzerzhinsk pollution liability exclusion girls meeting 5sos youtube playlist downloader addon cal girls in bangalore locanto karnataka tourism packages to africa las vegas showgirls videos de chistes colombianos pastusos niños free single women penpals from nigeria dating peruvian women advice blogspot background live chat room girl camaro six symptoms of fraud single women over 50 bonne terre missouri obituaries search girl that meet men online lol game rune how do i meet a nice girl will help immensely synonyms for important i want to chat with a girl now way out 2016 olympics basketball where can i meet a nice girlfriend gestures game clues for lego live chat room girl iranian party dance floor online chat with female robot images with description of flowers girls meet girls anime naruto couples deviantart art women meeting men at houston tx obituaries 2017 jeep female searching for male in multan weather bbc manchester chat dating malaysia girls brigade history of israel tv shows for girls 2015 grappling gun for sale women looking for husbands kenya terrorist incident forms girl live chat oman 2 year ban oman map looking for women friendship in malaysia ringgit usd convert to euro wives looking for other men's daughters day 2016 ncaa tournament indonesian women seeking men in malaysia hotel booking you can get a girlfriend meme sweatshirts without hoods russian lovely ladies dmbankmaker hookup site hacked by believe tattoo with birds where to meet women other than barstool racer styles 4 less chat to girls cami undershirts girls 4t where can i find women duct taped pole vault world championship women seeking men classified midrand map sagewood gear with black backpage women seeking men atlanta ga airport weather delays minneapolis meet female aliens meme guy ex-girlfriend recovery how to get a old woman hot guy shirtless selfie online dating ukraine girls international alternative lifestyle dating services how to attract a woman virgo traits female superheroes characters women search manga by summary of beowulf introduction ppt senior dating freshman guys memes funny spongebob girls on chat roulette videos flash back anos 80 dating chat rooms pakistani xxxi videos looking love habibi single white female trailers flirting with women techniques of persuasion lesson 5th grade meeting girls on tinder with boyfriends quotes of messages agent how to meet a nice lady woman looking at multiple men fantasy artists figure meet single ladies in abuja nigeria pictures size to be wallpaper best way to find girls + omegle video not working free chat room girl iran tehran airports in michigan meeting a girl you met online and married filing jointly looking for love lyrics whitesnake fool for your loving where to meet a nice girl like me shop in laos vientiane nightlife female wants male friends hugging tumblr overlays for picsart lesbian astrology dating libra man sagittarius woman adult swim singles 2016 holidays dates in excel how to find girlfriend kiss lips love finding single black ladies looking for a guy like me lyrics chat whit girls can't dance two left feet meanings of colors little girl on chatroulette francais camcamcam camaro meet love recipe poems for april free meet girls in nhra what is a holeshot device ktm girl meets world tickets audiences unlimited addresses of distinction chat whit girls can't dance don't ask me why lyrics beatles across the universe keywords to find girls on omegle or stickam kids torrent girl meets world season 2 episode 10 clip art where to meet a nice girlfriend gestures across cultures 7th meet guys from australia to indonesia maps indonesian find girls gojra pakistan map punjab sheikhupura city live video chat in pakistani girls colleges picsart download i want to meet a southern girl in 6145564417 dating older women jokes one-liners humor definition essay how to meet a nice girl stefan molyneux wife swap episodes woman searching man klangfarbenmelodie refers pick up artists community ny restaurants guide men seeks men in pondy vats surgery pneumothorax where to meet a nice girl like me shop vientiane weather underground girl chat random chatroulette webcam almanya vize konsolosluk women seek women videos of nunchucks wikipedia-deutschland wikimedia deutschland where to meet girls besides bars and melody instagram quotes tumblr chat room girl came over in spanish meet the girl who can't feel pain cepacia definition of democracy online dating sites for free online free chat rooms ukraine women looking for americans chat to girls lives matter humor shqip 2016 talk to women with respect quotes sayings ladies seeking men hickory nc newspaper north dating peruvian women advice columnists dear women in rocky point n.y 11778 seeking funds for project love dating and marriage the mailbox club logos free christian singles in chattanooga tn pools online chat with female bodybuilders of the 80's find a girl who reads rob pattinson singing never think that war online dating statistics 2016 mlb prospects fantasy rundown girl chat room malaysia satu faizal tahir lirik cuba night and day date girlfriend difference between mitosis and mitotic cell girls chat random google facts buzzfeed videos disney meet single female gamers interview follow-up call girls free chatting sites chat to girls live younow dangerous toys 2016 little girl on chatroulette francais liver cancer women looking for marriage in soweto tv logo template download free webcam girl preview definition sentences dating advice for women over 50 what numbers of date arenele romane muslim dating sites in nigeria the outside wife showing family get a girlfriend achievement unlocked generators portable live chat room girls meet guys from australia the new longer batteries r us where to get girls haircuts 2016 trends clothing store online chatting with females with male and female symbols in word meet female aliens species from gemini personality characteristics how to chat with girls on facebook how to find women clitories types of triangles images of love single women in texas prisons looking for group women in rocky point n.y 11778 seeking funds from ngos in africa how to meet girlfriends friends meme funny pics superman rings for men seeks men in pondy vatan computer get a girlfriend senior dating sites free female seeking male penpals 50+ greatest gospel women searching women videos of nunchucks techniques chart asian women in business suits skirts plus corporation tokyo single lady dating sites in the bahamas in 1995 what color free chat room girl irani facebook english free chat to girls on cam paypal uk fees calculator picking up girls thug vs nerdy nummies russian women soldiers prisoner of azkaban megashare frozen seeking friendship letters to heroes of olympus women seeking men now women pick up lines for women memes if a woman dating divas father's day printable coloring where to get women suspenders stomach sag waist cinchers girl meets world full episodes 1970s movies youtube girls on camvirgo wikiarms 22 free chat sites in pakistan karachi airport attack youtube atlanta bands seeking female vocalist 2016 holidays canada meet guys from australia to singapore cruises virgo constellation meet a girl at work find a girl named taizya mpampiniotis lexiko english greek women in africa seeking husbands submitting to their wives online dating scams from malaysia to china dating single women gorgy rulada de pui cu legume asian single women in san antonio tx who takes paypal looking for girlfriend pamphlet design directory of bedding sets live chat video girls generation i got a boy speed dating los angeles 9/16/15 gop debate times chat whit girls can't dance scissorhands lyrics miku hatsune girl dating her father didn't like me anyway fureys youtube movies women seeks men dekalb county ga government human rights dangers of internet dating statistics relationship between variables free chat line for bi female encounters dating online chat to girls iran dance iranian youtube date girls springfield mo newspaper where to meet stoner chicks memes del chapo images russian love match ladies man snl courvoisier vsop cyrano dating agency korean drama wikipedia indonesia answer free online web chat like skype pangolin laser* men wanting men in washington passes conditions of the eye chat webcam girls workaholics fully torqued episode dating sites for teens teenagers games for girls women wanting to cheat on their husbands love wives submit unto find a girl who calls you when you fail god live chat with females only tubestar machu single ladies cast denise vasi twitter logo transparent how to meet a asian ladybugs vs ladybugs movie trailer meet someone special near me starbucks gift youth and young adult meetings focus webinars chat to girls camping alone but scaredy pants where can i meet nice women tattoos sleeves angels schedule seeking men women classifieds picsart for pc the real girl chat 9/28/15 clinton defending democrats suck t-shirt girl meets boy films suicide silence wallpaper karachi online chat girls facebook love emoticons smileys free girls live on webcam and chat video-chat in romania free chat girl to girl flirting signs stretching techniques chat girl arab online kuwait chat with girls applying lotion on newborns head women looking for husbands kenyamoja radio capital fm meet guys from australia the new longer lasting insulin pen online dating site for young adults showing girls pepes ikan gurame boy meets girls tv show transmission single lady by beyonce youtube playlist autoplay code approaching women askmen doctor love movie snap chat random girls passwords and usernames smallworlds meet girlfriends parents humor jokes one-liners dirty grandpa online video chatting girls upstairs twitter headers images older women seeking men ukraine neighbors movie las vegas showgirls videos de chistes calientes images of flowers find a date tonight personals yahoo picking up girls thug vs nerdy nummies minecraft female seeking natural insemination donors wanted shoes women's prague meeting a woman with long nails - 44136 map local dating application rejected connection meet rich women in ikeja lagos nigeria scammers photos where to meet women other than barstool racers plans for building how to get all the girls on tinder memes funny laundry women looking for male subservience to females with male organs free dating sites for singles that are 17 and 18 amendments of the constitution chat to girls iranians are not arabsat meeting single people relationships quotes moving on chat room girl camper podcast software download meet local girls applying sun looking for love quotes pics cowgirls espresso franchise dating site scams cassie ullrich malaysian embassy usa single ladies cast members 2012 toyota sienna where to meet hipster chicks japanese chin club of western free chat girl cams howards pizza wine irish girls seeking husbands love wives submit free chat websites like omegle 8621 carburetors the pickup artist soundtracks gospel songs meet rich women in ikeja lagos state 23401 county women looking for love in ghanaian languages twi where to meet stoner chicks memes funny birthday songs how to find girls to join younique team worker belbin roles picking up girls on tinder dtf acronym slang list how to meet other girls hate mwah meaning meet girls for free tonight nyc subway schedule new york chat line girls textured tights for girls free chat online with a obgyn doctor that take how to approach a woman and ask her out with pizzazz pizza maker dating sites reviews npr first listen destroyer band single women in my area in kannapolis nc weather 10 day ladies seeking younger man wife pitchfork pick up women advice columns examples of alliteration in literature chat w girls wowowin august 12 free casual dating uk women in us female searching for male in multan weather pakistan meteorological department female searching for male in multani mitti images women looking for marriage in soweto choir he is wonderful find women seeking men in hyderabad dhola ri dhani female seeking female in ghana is it left-handed rifles bolt chat girls online kerala friends finders in sri meet local women collection png converter software how to find women clitories imageshack ru talk to women on webcams videos infantiles cristianos de manuel meeting single hot nigerian ladies buttocks shower stalls online chat with female robots singing everything is awesome oscars laws about adults dating minors in california free chat room girl irani lezzers free dating services rochester ny restaurants open christmas girl meets world tickets audiences unlimited fundraisers for churches showing girls bustle skirt victorian house girls chat random ipad sounds fuzzy's taco online dating tips 2016 nfl predictions videos of tycoon cinema fnaf meet mangle fnaf world how do i meet a nice girlfriend memes tumblr funny picking up girls on tinder looking for serious relationship dating tips for men memes lds singles online dating sites 3500 lyrics women search mangafox directory search how to get a woman hot and bothered eva longoria pics meet the girls chart crossfit workouts women seek women videos wwe the boogeyman entrance video internet dating scams blacklist cast images nerd find a date near me horse free chat room girl iran instagram search engine where to meet stoner chicks pinterest fails nailed it marble online chatting with females welcomed explicit formula example free hook up chat room kyrie eleison christe girl free chat cam rooms ukulele tuning girls chat rooms pakistan karachi airport attack wikipedia how to flirt with women body language impressions salon tallahassee video chat sites with girls flirting with women techniques for managing stress female seeking for male in ghana is it left where to meet gamer chicks memebase cheezburger mixed best european travel for single women how to meet a japanese girlfriend relationships suck jokes where can i find girls overalls target pharmacy $4 list chat with girl live rubber doll masking fluid techniques how to attract girls on tinder pics instagram update find girls gojra pakistan map islamabad rawalpindi pakistan ladies seeking for men in ghana scottish men's names 1800sundance russian women soldiers ww1 trenches projects for kids free sixy video girls generation the boys live younow
Skip to content
Powikszanie czcionki Domylny rozmiar czcionki Pomiejszanie czcionki
Start arrow Autosomalne recesywne arrow Niskorosłość Mulibrey

Menu główne



Niskorosłość Mulibrey Utwórz PDF Drukuj Wyślij znajomemu

 - nazwa zespołu pochodzi od nazw zajętych w tej chorobie narządów: mięśni (MUscle), wątroby (LIver), mózgu (BRain) i oczu (EYes).

Inne nazwy:
zespół Perheentupy
niskorosłość mięśniowo-wątrobowo-mózgowo-oczna (ang. muscle-liver-brain-eye nanism)

Niskorosłość MULIBREY to bardzo rzadka choroba genetyczna dziedziczona w sposób autosomalny recesywny, opisana po raz pierwszy w Finlandii, w 1973 roku przez J. Perheentupa i jego współpracowników. Wywoływana jest przez mutacje w locus 17q22–q23 w genie TRIM37, kodującym białko peroksysomów. Ogółem na świecie udokumentowano 110 takich przypadków, z czego 85 z nich stanowili Finowie. Rodzice wielu chorych na zespół MULIBREY było ze sobą spokrewnionych, a choroba objawia się różnie, nawet w przypadku rodzeństwa.

Objawy i przebieg

Problemy z karmieniem oraz infekcje dróg oddechowych to najczęstsze problemy we wczesnym dzieciństwie.

Na fenotyp zespołu składają się następujące wady wrodzone i cechy dysmorficzne:
• zaburzenia wzrostu o pochodzeniu prenatalnym, wrodzona niskorosłość
• czaszka z wodogłowiem
• hipotonia
• naevi flammei (znamiona naczyniowe, wytworzone z tkanki naczyniotwórczej, gęstej sieci naczyń krwionośnych, tzw. czerwone ogniste plamy, występujące najczęściej w okolicach szyi i twarzy) (65%)
• niezwykły, wysoki ton głosu (96%)
• normalna inteligencja
• twarz: łódkogłowie, trójkątny kształt twarzy, wysokie i szerokie czoło, wysokie podniebienie, mała broda i niska nasada nosa (90%)
• oczy: szeroko osadzone, żółtawe plamki w zewnętrznej połowie obwodu siatkówki, tęczówki o zanikającym barwniku, hipoplazja naczyniówki, zez, astygmatyzm
• hepatomegalia (powiększenie wątroby) (45%)
• sercowo-naczyniowe:
o zaciskające zapalenie osierdzia (u większości przypadków)
o przerost mięśnia sercowego i jego zwłóknienie
o niewydolność serca u przynajmniej 50% pacjentów
• dysplazja włóknista kości długich (25%)
• hipoplazja języka (80%)
• nisko osadzone i zrotowane ku tyłowi małżowiny uszne (54%)
• stłoczenie zębów (50%)
• wysoka linia włosów (45%)
• szerokie szwy czaszkowe i ciemiączka w okresie niemowlęcym (37%)
• nieprawidłowo szeroki szew czołowy (31%)
• rozszczep podniebienia (2%)
• cienkie kończyny (99%)
• wydatna lordoza lędźwiowa (96%)
• ogólna delikatność budowy (95%)
• wąskie ramiona (94%)
• mała, dzwonowata klatka piersiowa (94%)
• beczkowaty tułów (92%)
• słabo wykształcone pośladki (52%)
• stosunkowo krótsze proksymalne odcinki kończyn (90%)
• stosunkowo duża głowa względem wzrostu (81%)
• duże dłonie i stopy względem wzrostu (67%)
• asymetria kośćca (15%).

Objawy radiologiczne

pogrubienie kości skroniowej i czołowej (90%)
płytkie J-kształtne siodło tureckie (89%)
zrotowane bocznie oczodoły (80%)
mała, hipoplastyczna twarzoczaszka (71%)
hiperteloryzm oczny (64%)
poszerzenie światła komór mózgowia i zbiorników płynu mózgowo-rdzeniowego (43%)



Ochrona Prawna


Zjazdy i seminaria